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【预告】Development of Novel Rhodium-Catalyzed Cycloaddition and Cycloisomerization Reactions

时间:2016-06-16 阅读次数:
 【报告人】Weiping Tang

【报告题目】Development of Novel Rhodium-Catalyzed Cycloaddition and Cycloisomerization Reactions

【报告时间】2016627日上午9:00——10:30 报告时长:1.5小时

【报告地点】图书馆中心会议室                       

 

【报告内容简介】

    The Tang’s lab focuses on the development of new reactions initiated by acidic rodium catalysts. In the past decade, novel reactivity and numerous reactions were discovered for the acidic metal catalysts such as gold and platinum. For example, 1,2- and 1,3-acyloxy migration of paropargylic esters are the two typical reactions that were facilitated by gold catalysts. They found that rhodium complexes were also able to catalyze the above two transformations. On the other hand, rhodium is well-known for its ability to undergo oxidative addition, migratory insertion, and reductive elimination. The addition of gold-like reactivity to rhodium catalysis has led to the development of a number of new reactions from readily available materials in the Tang lab (Chem. Sov. Rev. 2012, 41, 7698.). The Tang lab also found that Rh(I) complexes with strong electron-deficient phosphine or phosphite ligands were also able to facilitate the above process and afford Rh(I) carbine intermediates. This discovery led to the realization of several intra- and intermolecular [5+2] cycloadditions of 3-acyloxy-1,4-enynes (Angew. Chem. Int. ed. 2011, 50, 8153; J. am. Chem. Soc. 2012, 134, 5211; Chem. Commun. 2013, 49, 2616; Angew. Chem. Int. ed. 2013, 52, 13601; Org. Lett. 2015, 17, 5128; J. Am. Chem. Sov. 2013, 135, 9271.).

 

【报告人简介】

Education:

  • B.S. 1997, Chemistry - Peking University
  • M.S. 1999, Chemistry - New York University
  • Ph.D. 2005, Organic Chemistry - Stanford University
  • Postdoc 2007, Medicinal Chemistry, Chemical Biology and Drug Discovery - Harvard University
  • 2007—present, University of Wisconsin-Madison

    His lab focuses on synthetic organic chemistry, medicinal chemistry, and chemical biology. He has more than 100 publications, of which most are published on J. Am. Chem. Soc., Angew. Chem. Int. Ed., Org. Lett., and others.